Yeafesh Osman (ইয়াফেস ওসমান) is a Bangladeshi architect and politician and the former Minister of Science and Technology of Government of Bangladesh since 2015. He worked under Fazlur Rahman Khan, the notable architect of Sears Tower.

Osman was born in Chittagong in 1946 to novelist Shawkat Osman. His brother Bulbon Osman is an artist and writer. He studied in Chittagong Muslim High School and later passed his Secondary School Certificate and Higher Secondary School Certificate examinations from Siddheswari Boys' High School and Notre Dame College, Dhaka respectively. He completed his graduation in architecture from Bangladesh University of Engineering and Technology.

Osman was appointed as the State Minister of Science and Technology (Technocrat) in 2014 and then became cabinet minister on 14 July 2015.