Lutho Sipamla (লুথো সিপামলা) is a South African professional cricketer who plays domestic cricket for Gauteng. He made his international debut for the South Africa cricket team in February 2019.

He made his first-class debut for Eastern Province in the 2016–17 Sunfoil 3-Day Cup on 5 January 2017. Prior to his debut, he was named in South Africa's squad for the 2016 Under-19 Cricket World Cup. He made his List A debut for Eastern Province in the 2016–17 CSA Provincial One-Day Challenge on 12 February 2017.

In September 2018, he was named in Eastern Province's squad for the 2018 Africa T20 Cup. He made his Twenty20 debut for Eastern Province in the 2018 Africa T20 Cup on 14 September 2018.

In October 2018, he was named in Tshwane Spartans' squad for the first edition of the Mzansi Super League T20 tournament. He was the joint-leading wicket-taker for the team in the tournament, with sixteen dismissals in ten matches. In August 2019, he was named the Mzansi Super League Young Player of the Year at Cricket South Africa's annual award ceremony.

In July 2018, he was named in the Cricket South Africa Emerging Squad. In January 2019, he was named in South Africa's Twenty20 International (T20I) squad for their series against Pakistan. He made his T20I debut for South Africa against Pakistan on 3 February 2019. In January 2020, he was named in South Africa's One Day International (ODI) squad for their series against England. He made his ODI debut on 4 February 2020, for South Africa against England.

In December 2020, Sipamla was added to South Africa's Test squad for their series against Sri Lanka. He made his Test debut for South Africa, against Sri Lanka, on 26 December 2020.