Born in Kelvedon, Essex, he moved to Colchester at 10 months old. Spurgeon's conversion from nominal Congregationalism came on 6 January 1850, at age 15. On his way to a scheduled appointment, a snowstorm forced him to cut short his intended journey and to turn into a Primitive Methodist chapel in Artillery Street, Newtown, Colchester, where he believed God opened his heart to the salvation message. The text that moved him was Isaiah 45:22 ("Look unto me, and be ye saved, all the ends of the earth, for I am God, and there is none else"). Later that year, on 4 April, he was admitted to the church at Newmarket. His baptism followed on 3 May in the river Lark, at Isleham. Later that same year he moved to Cambridge, where he later became a Sunday school teacher. Spurgeon preached his first sermon in the winter of 1850–51 in a cottage at Teversham while filling in for a friend. From the beginning of Spurgeon's ministry, his style and ability were considered to be far above average. In the same year, he was installed as pastor of the small Baptist church at Waterbeach, Cambridgeshire, where he published his first literary work, a Gospel tract written in 1853.

In April 1854, after preaching three months on probation and just four years after his conversion, Spurgeon, then only 19 years old, was called to the pastorate of London's famed New Park Street Chapel in Southwark (formerly pastored by the Particular Baptists Benjamin Keach, and theologian John Gill). This was the largest Baptist congregation in London at the time, although it had dwindled in numbers for several years. Spurgeon found friends in London among his fellow pastors, such as William Garrett Lewis of Westballs Grove Church, an older man who along with Spurgeon went on to found the London Baptist Association.

Within a few months of Spurgeon's arrival at Park Street, his ability as a preacher made him famous. The following year the first of his sermons in the "New Park Street Pulpit" was published. Spurgeon's sermons were published in printed form every week and had a high circulation. By the time of his death in 1892, he had preached nearly 3,600 sermons and published 49 volumes of commentaries, sayings, anecdotes, illustrations and devotions.

Immediately following his fame was criticism. The first attack in the press appeared in the Earthen Vessel in January 1855. His preaching, although not revolutionary in substance, was a plain-spoken and direct appeal to the people, using the Bible to provoke them to consider the teachings of Jesus Christ. Critical attacks from the media persisted throughout his life. The congregation quickly outgrew their building, and moved to Exeter Hall, then to Surrey Music Hall. At 22, Spurgeon was the most popular preacher of the day.

On 8 January 1856, Spurgeon married Susannah, daughter of Robert Thompson of Falcon Square, London, by whom he had twin sons, Charles and Thomas born on September 20, 1856. At the end of that year, tragedy struck on 19 October 1856, as Spurgeon was preaching at the Surrey Gardens Music Hall for the first time. Someone in the crowd yelled, "FIRE" The ensuing panic and stampede left several dead. Spurgeon was emotionally impacted by the event and it had a sobering influence on his life. For many years he spoke of being moved to tears for no reason known to himself.

a congregation consisting of 10,000 souls, streaming into the hall, mounting the galleries, humming, buzzing, and swarming – a mighty hive of bees – eager to secure at first the best places, and, at last, any place at all. After waiting for more than half an hour – for if you wish to have a seat you must be there at least that space of time in advance… Mr. Spurgeon ascended his tribune. To the hum, rush, and trampling of men, succeeded a low, concentrated thrill and murmur of devotion, which seemed to run at once, like an electric current, through the breast of everyone present, and by this magnetic chain the preacher held us fast bound for about two hours. It is not my purpose to give a summary of his discourse. It is enough to say of his voice, that its power and volume are sufficient to reach everyone in that vast assembly; of his language that it is neither high-flown nor homely; of his style, that it is at times familiar, at times declamatory, but always happy, and often eloquent; of his doctrine, that neither the 'Calvinist' nor the 'Baptist' appears in the forefront of the battle which is waged by Mr. Spurgeon with relentless animosity, and with Gospel weapons, against irreligion, cant, hypocrisy, pride, and those secret bosom-sins which so easily beset a man in daily life; and to sum up all in a word, it is enough to say, of the man himself, that he impresses you with a perfect conviction of his sincerity.

A controversy among the Baptists flared in 1887 with Spurgeon's first "Down-grade" article, published in The Sword & the Trowel. In the ensuing "Downgrade Controversy," the Metropolitan Tabernacle disaffiliated from the Baptist Union, effectuating Spurgeon's congregation as the world's largest self-standing church. Spurgeon framed the controversy in this way:

Believers in Christ's atonement are now in declared union with those who make light of it; believers in Holy Scripture are in confederacy with those who deny plenary inspiration; those who hold evangelical doctrine are in open alliance with those who call the fall a fable, who deny the personality of the Holy Ghost, who call justification by faith immoral, and hold that there is another probation after death… It is our solemn conviction that there should be no pretence of fellowship. Fellowship with known and vital error is participation in sin.

The Controversy took its name from Spurgeon's use of the term "Downgrade" to describe certain other Baptists' outlook toward the Bible (i.e., they had "downgraded" the Bible and the principle of sola scriptura). Spurgeon alleged that an incremental creeping of the Graf-Wellhausen hypothesis, Charles Darwin's theory of evolution, and other concepts were weakening the Baptist Union. Spurgeon emphatically decried the doctrine that resulted:

Assuredly the New Theology can do no good towards God or man; it, has no adaptation for it. If it were preached for a thousand years by all the most earnest men of the school, it would never renew a soul, nor overcome pride in a single human heart.

Spurgeon strongly opposed the owning of slaves. He lost support from the Southern Baptists, sales of his sermons dropped, and he received scores of threatening and insulting letters as a consequence.

In a letter to the Christian Watchman and Reflector (Boston), Spurgeon declared:

Like other Baptists of his time, despite opposing Dispensationalism,Spurgeon anticipated the restoration of the Jews to inhabit the Promised Land.

We look forward, then, for these two things. I am not going to theorize upon which of them will come first – whether they shall be restored first, and converted afterwards – or converted first and then restored. They are to be restored and they are to be converted, too. The Restoration And Conversion of the Jews. Ezekiel 37.1–10, June 16th, 1864