Luis Fernando Muriel Fruto (লুইস ফার্নান্দো মুরিয়েল ফ্রুটো) is a Colombian professional footballer who plays as a forward for Major League Soccer club Orlando City.

Having started his professional career with Colombian side Deportivo Cali, Muriel joined Udinese. His first two seasons at the club saw him loaned out to Granada and Lecce respectively before returning to the club in 2012, during which year he won the Serie A Best Young Revelation award alongside Stephan El Shaarawy. After scoring 15 league goals in 57 appearances, Muriel joined fellow Serie A side Sampdoria in January 2015. He spent two and a half seasons with the club, scoring 21 goals in 79 league appearances before joining Sevilla in 2017. In January 2019, he was sent back to Italy on loan with Fiorentina. In June 2019, Muriel signed for Atalanta for a reported €18 million. In his first season, he recorded 18 league goals and guided Atalanta to UEFA Champions League qualification for the first time in the club's history. The following season, he finished as the third top goalscorer in the Serie A, behind only Cristiano Ronaldo and Romelu Lukaku. Consequently, Atalanta qualified for a second consecutive Champions League tournament; for his efforts, Muriel was included in the 2020–21 Serie A Team of the Year.

Muriel represented Colombia at U20 level and featured for the nation at the 2011 FIFA U-20 World Cup for which Colombia were the host nation. On 6 August 2011, having previously scored twice against France, he scored the only goal of the match as Colombia defeated South Korea 1–0 to progress from the group stages with a perfect record. Muriel ultimately scored four goals for the tournament before Colombia were knocked out by Mexico in the quarter-finals.

Muriel received his first senior call-up by José Pékerman in 2012 and debuted in a 1–0 World Cup qualifier loss against Ecuador on 10 June.

On 6 February 2013, he scored his first goal in a friendly match against Guatemala. The following year, he was one of seven players cut from Colombia's extended squad for the 2014 FIFA World Cup in Brazil. He was a member of Colombia's squad for the 2015 Copa América but was overlooked for the Copa América Centenario the following year.

In May 2018 he was named in Colombia's preliminary 35-man squad for the 2018 FIFA World Cup in Russia. He featured sporadically as Colombia reached the Round of 16 where they were eliminated following a penalty shoot-out defeat to England. The following summer, Muriel was included in the 23-man Colombia squad for the 2019 Copa América in Brazil.

In his youth, Muriel was often praised in the media for his precocious performances during his early career in Italy, which led him to win the Serie A Best Young Revelation Award in 2012. Several footballing figures in Italy, such as manager Massimiliano Allegri, have recognised Muriel for his speed and technique on the ball, as well as the potential which he already demonstrated as a youngster; his former Udinese teammate Antonio Di Natale even compared him to Alexis Sánchez in 2013. Although Muriel is usually deployed as a centre-forward, he is a versatile forward, who is capable of playing in several offensive positions; indeed, during the 2012–13 season, under his former Udinese manager Francesco Guidolin, he also demonstrated his creative capabilities in a more withdrawn, central role behind another striker, which frequently saw him operate as either a second striker or attacking midfielder. He is also capable of playing as a winger. A fast, talented, creative, two-footed, and technically gifted striker, with good dribbling skills, pace, agility, acceleration, movement, and an eye for goal, Muriel's playing style, physical build, and appearance have led him to be compared to former Brazil striker Ronaldo. Muriel has stated that this comparison is likely due to the fact that, as a youngster, he was an admirer of Ronaldo during the latter's time with Inter Milan. Muriel went on to say that he supported Inter Milan because Ronaldo was playing for them at the time, and that he was initially a Milan fan. Coincidentally, Muriel also stated that, like his childhood idol, he also suffers from weight issues, and even had to lose five kg at one point during the 2012–13 season. This meant that he had to be consistent with his fitness regime, which enabled him to achieve a similar level of athletic ability to Ronaldo. Aside from Ronaldo, another one of Muriel's major influences as a footballer in his youth was compatriot Iván Valenciano. Despite his ability, he is also known to be inconsistent.